Arbloc CCB Description

Each film-coated tablet contains: Amlodipine (as besilate) 5 mg and Losartan (as Potassium) 50 mg or 100 mg.
Amlodipine + Losartan contains the besilate salt of Amlodipine, a dihydropyridine calcium channel blocker (CCB). Amlodipine besilate is a white to pale yellow crystalline powder, slightly soluble in water and sparingly soluble in ethanol. Amlodipine besilate's chemical name is 3-ethyl-5methyl(±)-2-[(2-aminoethoxy)methyl]-4-(2chlorophenyl)-6-methyl-1, 4-dihydropyridine-3,5-dicarboxylate benzensulphonate. Its empirical formula is C₂₀H₂₅ClN₂O₅·C₆H₆O₃S and its molecular weight is 567.1.
Losartan potassium is an angiotensin II receptor (type ATI) antagonist. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(O-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt. Losartan potassium is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohol, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-Hydroxymethyl group on the imidazole ring results in the active metabolite of Losartan.